Bisphosphonate-related osteonecrosis of the jaw
نویسندگان
چکیده
Bisphosphonates (BPs) have been used for the management of bone metabolic diseases. Currently their therapeutic use has increased, as also have their adverse effects, one of the most important being the bisphosphonate-related osteonecrosis of the jaw (BRONJ), a complication of diffi cult treatment and solution. Until now, the physiopathology of BRONJ remains unclear, and its treatment is uncertain. Although the literature provides several treatment options, there is no defi ned protocol. We present a review about BRONJ, focusing on its pathogenesis and its reported forms of treatment.
منابع مشابه
Bisphosphonate osteonecrosis of the jaw: a literature review of UK policies versus international policies on the management of bisphosphonate osteonecrosis of the jaw.
Despite the increasing number of cases of osteonecrosis of the jaws related to bisphosphonate therapy described in the literature there is a paucity of evidence-based treatment for the condition. In this second article on bisphosphonate-related jaw complications we discuss the different treatment strategies for the condition, review current literature, particularly in relation to the recommenda...
متن کاملOsteonecrosis Related to Oral Bisphosphonate Usage: Case Report and Review of Treatment Strategies
Bisphosphonates are a class of agents used to treat osteoclast-mediated bone diseases and many neoplasm types. Osteonecrosis of the jaw is a common side effect of bisphosphonate therapy, presenting as exposed and necrotic maxillary and/or mandibular bone. In this report, we present a case of bisphosphonate-related osteonecrosis of the jaw in a patient who received oral alendronate therapy due t...
متن کاملReeconstruction of a mandibular defect after bisphosphonate-related osteonecrosis of the jaw.
We describe the reconstruction of a mandible damaged by bisphosphonate-related osteonecrosis of the jaw (BRONJ) using the simple and safe combination of a reconstruction plate and patching with a submandibular gland.
متن کاملBiomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2013; 157:XX
Aim. This article covers the authors‘ experience with the treatment of bisphosphonate-related osteonecrosis of the jaw in 11 individuals. Methods. A retrospective study of patients diagnosed and treated for bisphosphonate-related osteonecrosis of the jaw at the Department of Dentistry, University Hospital Hradec Králové during the period January 2006 to October 2012. The treatment protocol cons...
متن کاملBiomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015 Jun; 159(2)
Aim. This article covers the authors‘ experience with the treatment of bisphosphonate-related osteonecrosis of the jaw in 11 individuals. Methods. A retrospective study of patients diagnosed and treated for bisphosphonate-related osteonecrosis of the jaw at the Department of Dentistry, University Hospital Hradec Králové during the period January 2006 to October 2012. The treatment protocol cons...
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